These are Thiel's seven questions every business / entrepreneur must answer (ideally before starting out).

1. Engineering Question.
- Can you create breakthrough tech instead of incremental upgrades?

2. Timing Question
- Is now the right time to start a business?

3. The Monopoly Question
- Are you starting with a big share of a small market?

4. People Question
- Do you have the right team?

5. Distribution Question
- Do you have a way of not just create but share your product?

6. Defensibility Question
- Will your market position be defensible in 10-20 years?

7. Secret Question
- Have you identified a unique opportunity others don't see?

Reference:

Zero to One, Peter Thiel (Page 153)